Article
An endoribonuclease-prepared siRNA screen in human cells identifies genes essential for cell division.
Nature - 23 Dec 2004
Kittler Ralf, Putz Gabriele, Pelletier Laurence, Poser Ina, Heninger Anne-Kristin, Drechsel David, Fischer Steffi, Konstantinova Irena, Habermann Bianca, Grabner Hannes, Yaspo Marie-Laure, Himmelbauer Heinz, Korn Bernd, Neugebauer Karla, Pisabarro Maria Teresa, Buchholz Frank
Abstract excerpt
RNA interference (RNAi) is an evolutionarily conserved defence mechanism whereby genes are specifically silenced through degradation of messenger RNAs; this process is mediated by homologous double-stranded (ds)RNA molecules. In invertebrates, long dsRNAs have been used for genome-wide screens and have provided insights into gene functions. Because long dsRNA triggers a nonspecific interferon response in many...
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