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Article

Loss of function of p16 gene and prognosis of pulmonary adenocarcinoma

20 Dec 2004

Abstract excerpt

BACKGROUND: Stepwise progression of peripheral-type lung adenocarcinoma was characterized morphologically and was related to prognosis. Expression of the tumor suppressor gene p16 in pulmonary adenocarcinoma decreased, mainly as a result of aberrant methylation of the CpG islands of the promoter region. METHODS: Aberrant methylation status of the p16 promoter region, the expression of its product, and loss of...

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PMID: 15612080
DOI: 10.1002/cncr.20827

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