Article
Association of p16 homozygous deletions with clinicopathologic characteristics and EGFR/KRAS/p53 mutations in lung adenocarcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Jun 2008
Iwakawa Reika, Kohno Takashi, Anami Yoichi, Noguchi Masayuki, Suzuki Kenji, Matsuno Yoshihiro, Mishima Kazuhiko, Nishikawa Ryo, Tashiro Fumio, Yokota Jun
Abstract excerpt
PURPOSE: The p16 gene is frequently inactivated in lung adenocarcinoma. In particular, homozygous deletions (HD) have been frequently detected in cell lines; however, their frequency and specificity is not well-established in primary tumors. The purpose of this study was to elucidate the prevalence and the timing for the occurrence of p16 HDs in lung adenocarcinoma progression in vivo. EXPERIMENTAL DESIGN:...
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