Article
Increase in the frequency of p16INK4 gene inactivation by hypermethylation in lung cancer during the process of metastasis and its relation to the status of p53.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Nov 2000
Seike M, Gemma A, Hosoya Y, Hemmi S, Taniguchi Y, Fukuda Y, Yamanaka N, Kudoh S
Abstract excerpt
The p16INK4 gene, which is a tumor suppressor gene, is frequently altered in lung cancers. Hypermethylation of the promoter region of the p16INK4 gene seems to be the major mechanism through which p16INK4 become inactivated. Hypermethylation of the p16INK4 gene was reported to occur at an early stage in lung cancer. To determine whether the change in p16INK4 methylation status occurs at the late stage in the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.