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Article

Frequent Aberrant Methylation of <i>p16</i><sup><i>INK4a</i></sup> in Primary Rat Lung Tumors

1 Mar 1997

Abstract excerpt

The p16INK4a (p16) tumor suppressor gene is frequently inactivated by homozygous deletion or methylation of the 5' CpG island in cell lines derived from human non-small-cell lung cancers. However, the frequency of dysfunction in primary tumors appears to be significantly lower than that in cell lines. This discordance could result from the occurrence or selection of p16 dysfunction during cell culture....

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PMID: 9032263
DOI: 10.1128/mcb.17.3.1366

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