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Article

Genetic variants at the miR-124 binding site on the cytoskeleton-organizing IQGAP1 gene confer differential predisposition to breast cancer.

International journal of oncology - 1 Apr 2011

Zheng Hong, Song Fengju, Zhang Lina, Yang Da, Ji Ping, Wang Yingmei, Almeida Maria, Calin George A, Hao Xishan, Wei Qingyi, Zhang Wei, Chen Kexin

Abstract excerpt

IQGAP1 knockout mice develop gastric cancer, but the IQGAP1 protein is associated with some advanced-stage human cancers. IQGAP1 expression is regulated by a microRNA, miR-124, through a binding site at the 3'-untranslated region, where a single nucleotide polymorphism (SNP) exists in the core binding region. We asked whether IQGAP1 expression is associated with breast cancer development and whether genetic...

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Identifiers

PMID: 21318219
DOI: 10.3892/ijo.2011.940

Genes

IQGAP1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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