A functional single nucleotide polymorphism in mucin 1, at chromosome 1q22, determines susceptibility to diffuse-type gastric cancer.

doi:10.1053/j.gastro.2010.10.058

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A functional single nucleotide polymorphism in mucin 1, at chromosome 1q22, determines susceptibility to diffuse-type gastric cancer.

Gastroenterology - 1 Mar 2011

Saeki Norihisa, Saito Akira, Choi Il Ju, Matsuo Keitaro, Ohnami Sumiko, Totsuka Hirohiko, Chiku Suenori, Kuchiba Aya, Lee Yeon-Su, Yoon Kyong-Ah, Kook Myeong-Cherl, Park Sook Ryun, Kim Young-Woo, Tanaka Hideo, Tajima Kazuo, Hirose Hiroshi, Tanioka Fumihiko, Matsuno Yoshihiro, Sugimura Haruhiko, Kato Shunji, Nakamura Tsuneya, Nishina Tomohiro, Yasui Wataru, Aoyagi Kazuhiko, Sasaki Hiroki, Yanagihara Kazuyoshi, Katai Hitoshi, Shimoda Tadakazu, Yoshida Teruhiko, Nakamura Yusuke, Hirohashi Setsuo, Sakamoto Hiromi

Abstract excerpt

BACKGROUND & AIMS: Two major types of gastric cancer, intestinal and diffuse, develop through distinct mechanisms; the diffuse type is considered to be more influenced by genetic factors, although the mechanism is unknown. Our previous genome-wide association study associated 3 single nucleotide polymorphisms (SNPs) with diffuse-type gastric cancer (DGC); 1 was a functional SNP (rs2294008) in prostate stem cell...

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PMID: 21070779
DOI: 10.1053/j.gastro.2010.10.058

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MUC1
PSCA

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