Article
E-cadherin gene mutations provide clues to diffuse type gastric carcinomas.
Cancer research - 15 Jul 1994
Becker K F, Atkinson M J, Reich U, Becker I, Nekarda H, Siewert J R, Höfler H
Abstract excerpt
The calcium-dependent homophilic cell adhesion molecule and candidate suppressor gene, E (epithelial)-cadherin, plays a major role in the organization and integrity of most epithelial tissues. Diffusely growing gastric carcinomas show markedly reduced homophilic cell-to-cell interactions. We spec...
Topics
- Base Sequence
- Cadherins
- Chromosome Deletion
- Humans
- Lymphatic Metastasis
- Molecular Sequence Data
- Mutation
- Polymerase Chain Reaction
- RNA, Messenger
- Stomach Neoplasms