Article
The T8590C polymorphism of CYP4A11 and 20-hydroxyeicosatetraenoic acid in essential hypertension.
Hypertension (Dallas, Tex. : 1979) - 1 Mar 2008
Laffer Cheryl L, Gainer James V, Waterman Michael R, Capdevila Jorge H, Laniado-Schwartzman Michal, Nasjletti Alberto, Brown Nancy J, Elijovich Fernando
Abstract excerpt
A role for a deficit in transport actions of 20-hydroxyeicosatetraenoic acid (20-HETE) in hypertension is supported by the following: (1) diminished renal 20-HETE in Dahl-S rats; (2) altered salt- and furosemide-induced 20-HETE responses in salt-sensitive hypertensive subjects; and (3) increased population risk for hypertension in C allele carriers of the T8590C polymorphism of CYP4A11, which encodes an enzyme...
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