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Article

A haplotype of the CYP4A11 gene associated with essential hypertension in Japanese men.

Journal of hypertension - 1 Mar 2008

Fu Zhenyan, Nakayama Tomohiro, Sato Naoyuki, Izumi Yoichi, Kasamaki Yuji, Shindo Atsushi, Ohta Masakatsu, Soma Masayoshi, Aoi Noriko, Sato Mikano, Ozawa Yukio, Ma Yitong

Abstract excerpt

OBJECTIVE: CYP4A11, a member of the cytochrome P450 family, acts mainly as an enzyme that converts arachidonic acid to 20-hydroxyeicosatetraenoic acid, a metabolite involved in blood pressure regulation in humans. Disruption of the murine cyp4a14 and cyp4a10 genes, homologues of human CYP4A11, was reported recently to cause hypertension. The gene-disrupted male mice had higher blood pressure than the...

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PMID: 18300855
DOI: 10.1097/HJH.0b013e3282f2f10c

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