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Article

Regulated insulin delivery from human epidermal cells reverses hyperglycemia.

Molecular therapy : the journal of the American Society of Gene Therapy - 1 Jun 2008

Tian Jun, Lei Pedro, Laychock Suzanne G, Andreadis Stelios T

Abstract excerpt

Alternative insulin therapies are being sought that will provide euglycemic control for people with diabetes mellitus. The epidermis is a self-renewing tissue that is easily accessible and can provide large numbers of autologous cells that can be used for generating insulin-secreting skin substitutes. Lentiviral vectors have been engineered to produce a fusion protein between the furin-cleavable proinsulin and...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18431361
DOI: 10.1038/mt.2008.79

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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