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A viral insulin-like peptide inhibits IGF-1 receptor phosphorylation and regulates IGF1R gene expression

3 Jan 2024

Abstract excerpt

OBJECTIVE: The insulin/IGF superfamily is conserved across vertebrates and invertebrates. Our team has identified five viruses containing genes encoding viral insulin/IGF-1 like peptides (VILPs) closely resembling human insulin and IGF-1. This study aims to characterize the impact of Mandarin fish ranavirus (MFRV) and Lymphocystis disease virus-Sa (LCDV-Sa) VILPs on the insulin/IGF system for the first time....

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PMID: 38182007
DOI: 10.1016/j.molmet.2023.101863

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