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Article

Association of amino acid substitution polymorphisms in DNA repair genes TP53, POLI, REV1 and LIG4 with lung cancer risk.

International journal of cancer - 1 May 2005

Sakiyama Tokuki, Kohno Takashi, Mimaki Sachiyo, Ohta Tsutomu, Yanagitani Noriko, Sobue Tomotaka, Kunitoh Hideo, Saito Ryusei, Shimizu Kimiko, Hirama Chie, Kimura Junko, Maeno Go, Hirose Hiroshi, Eguchi Takashi, Saito Daizo, Ohki Misao, Yokota Jun

Abstract excerpt

Single nucleotide polymorphisms (SNPs) were searched for in 36 genes involved in diverse DNA repair pathways, and 50 nonsynonymous (associated with amino acid changes) SNPs identified were assessed for associations with lung cancer risk by a case-control study consisting of 752 adenocarcinoma cases, 250 squamous cell carcinoma cases and 685 controls. An SNP, Arg72Pro, of the TP53 gene encoding a DNA damage...

Read the complete abstract on PubMed

Topics

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Share to Amino Acids
Share to Carcinoma, Squamous Cell

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Ligase ATP

Share to DNA Ligases

Share to DNA Polymerase I

Share to Genes, p53

Share to Nucleotidyltransferases

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Source

Identifiers

PMID: 15609317
DOI: 10.1002/ijc.20790

Genes

POLI
LIG4
REV1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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