Article
An analysis of single nucleotide polymorphisms of 125 DNA repair genes in the Texas genome-wide association study of lung cancer with a replication for the XRCC4 SNPs.
DNA repair - 3 Apr 2011
Yu Hongping, Zhao Hui, Wang Li-E, Han Younghun, Chen Wei V, Amos Christopher I, Rafnar Thorunn, Sulem Patrick, Stefansson Kari, Landi Maria Teresa, Caporaso Neil, Albanes Demetrius, Thun Michael, McKay James D, Brennan Paul, Wang Yufei, Houlston Richard S, Spitz Margaret R, Wei Qingyi
Abstract excerpt
DNA repair genes are important for maintaining genomic stability and limiting carcinogenesis. We analyzed all single nucleotide polymorphisms (SNPs) of 125 DNA repair genes covered by the Illumina HumanHap300 (v1.1) BeadChips in a previously conducted genome-wide association study (GWAS) of 1154 lung cancer cases and 1137 controls and replicated the top-hits of XRCC4 SNPs in an independent set of 597 cases and...
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