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Article

APEX1 Asp148Glu gene polymorphism is a risk factor for lung cancer in relation to smoking in Japanese.

Asian Pacific journal of cancer prevention : APJCP - 1 Jan 2010

Osawa Kayo, Miyaishi Aiko, Uchino Kazuya, Osawa Yasunori, Inoue Natsuko, Nakarai Chiaki, Tsutou Akimitsu, Kido Yoshiaki, Yoshimura Masahiro, Tsubota Noriaki, Takahashi Juro

Abstract excerpt

DNA repair enzymes play an important role in the development of various kinds of cancer. We here analyzed associations of XPD Lys751Gln, APEX1 Asp148Glu, XRCC1 Arg399Gln, and XRCC3 Thr241Met gene polymorphisms in DNA repair pathways in relation to the risk of lung cancer using PCR-RFLP. The study involved 104 lung cancer patients and 120 non-cancer controls divided into non-smokers and smokers. We found a...

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Identifiers

PMID: 21198260

Genes

APEX1
XRCC1
XRCC3

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