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Article

A functional polymorphism of the mu-opioid receptor gene (OPRM1) influences cue-induced craving for alcohol in male heavy drinkers.

Alcoholism, clinical and experimental research - 1 Jan 2007

van den Wildenberg Esther, Wiers Reinout W, Dessers Joelle, Janssen Rob G J H, Lambrichs Ellen H, Smeets Hubert J M, van Breukelen Gerard J P

Abstract excerpt

BACKGROUND: The mu-opioid receptor gene (OPRM1) codes for the mu-opioid receptor, which binds beta-endorphin. The A118G polymorphism in this gene affects beta-endorphin binding such that the Asp40 variant (G allele) binds beta-endorphin 3 times more tightly than the more common Asn40 variant (A allele). This study investigated the influence of the A118G polymorphism on cue reactivity after exposure to an...

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Source

Identifiers

PMID: 17207095
DOI: 10.1111/j.1530-0277.2006.00258.x

Genes

OPRM1

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A functional polymorphism of the mu-opioid receptor gene (OPRM1) influences cue-induced craving for alcohol in male heavy drinkers.PMID 17207095Read ↗

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