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Prion Protein Fragment 106–126 Induces a p38 MAP Kinase—Dependent Apoptosis in SH‐SY5Y Neuroblastoma Cells Independently from the Amyloid Fibril Formation

1 Dec 2003

Abstract excerpt

Prion diseases are neurodegenerative disorders of the central nervous system of humans and animals, characterized by spongiform degeneration of the central nervous system, astrogliosis, and deposition of amyloid into the brain. The conversion of a cellular glycoprotein (prion protein, PrP(C)) into an altered isoform (PrP(Sc)) has been proposed to represent the causative event responsible for these diseases. The...

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PMID: 15033801
DOI: 10.1196/annals.1299.114

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Prion Protein Fragment 106–126 Induces a p38 MAP Kinase—Dependent Apoptosis in SH‐SY5Y Neuroblastoma Cells Independently from the Amyloid Fibril FormationPMID 15033801Read ↗

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