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Article

Prion protein with an octapeptide insertion has impaired neuroprotective activity in transgenic mice.

The EMBO journal - 6 Jun 2007

Li Aimin, Piccardo Pedro, Barmada Sami J, Ghetti Bernardino, Harris David A

Abstract excerpt

Familial prion diseases are due to dominantly inherited, germline mutations in the PRNP gene that encodes the prion protein (PrP). The cellular mechanism underlying the pathogenic effect of these mutations remains uncertain. To investigate whether pathogenic mutations impair a normal, physiological activity of PrP, we have crossed Tg(PG14) mice, which express PrP with an octapeptide insertion associated with an...

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Identifiers

PMID: 17510630
DOI: 10.1038/sj.emboj.7601726
PMCID: PMC1888682

Genes

PRNP

Provenance

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Source receipt: pubmed, retrieved 7 Sept 2026.

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