Article
The effects of hepatic fibrosis on Ito cell gene expression.
Matrix (Stuttgart, Germany) - 1 Feb 1992
Weiner F R, Shah A, Biempica L, Zern M A, Czaja M J
Abstract excerpt
While Ito cells appear to be a major source of increased matrix synthesis during hepatic fibrogenesis, the cellular changes that occur in these cells during liver fibrosis have not been well delineated. In this study we examined Ito cell gene expression in isolated cells from normal rats, and rats with carbon tetrachloride-induced fibrosis, in order to better define the changes occurring in these cells during...
Topics
- Animals
- Carbon Tetrachloride
- Endothelium
- Extracellular Matrix Proteins
- Gene Expression Regulation
- Kupffer Cells
- Liver Cirrhosis, Experimental
- Male
- Neoplasm Proteins
- Phenotype
- RNA, Messenger