Article
Regulation of the alpha 2(I) collagen gene transcription in fat-storing cells derived from a cirrhotic liver.
Hepatology (Baltimore, Md.) - 1 Aug 1995
Inagaki Y, Truter S, Greenwel P, Rojkind M, Unoura M, Kobayashi K, Ramirez F
Abstract excerpt
Fat-storing cells (FSC) are the main producers of type I collagen in both normal and fibrotic livers. In order to elucidate the molecular mechanisms controlling collagen expression in FSC, we examined the transcription of the alpha 2(I) collagen gene (COL1A2) in two distinct FSC clones, CFSC-2G a...
Topics
- Adipocytes
- Animals
- Binding Sites
- Blotting, Northern
- Carbon Tetrachloride
- Collagen
- Gene Expression Regulation
- Humans
- Liver Cirrhosis, Experimental
- Nuclear Proteins
- Phenotype
- RNA, Messenger