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Article

Activation of Ito cells involves regulation of AP-1 binding proteins and induction of type I collagen gene expression.

The Biochemical journal - 15 Dec 1994

Armendariz-Borunda J, Simkevich C P, Roy N, Raghow R, Kang A H, Seyer J M

Abstract excerpt

Activation of liver Ito cells is characterized by increased proliferation, fibrogenesis, loss of cellular retinoid and change of cell-shape. Here, we have described fundamental differences between freshly isolated Ito cells (FIC) and long-term cultured Ito cells (LTIC). This process of activation correlates with the absence of expression of Pro alpha 1(I) gene in FIC. LTIC expressed abundant transcripts of Pro...

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Identifiers

PMID: 7818486
DOI: 10.1042/bj3040817
PMCID: PMC1137407

Genes

CAT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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