Article
Activation of Ito cells involves regulation of AP-1 binding proteins and induction of type I collagen gene expression.
The Biochemical journal - 15 Dec 1994
Armendariz-Borunda J, Simkevich C P, Roy N, Raghow R, Kang A H, Seyer J M
Abstract excerpt
Activation of liver Ito cells is characterized by increased proliferation, fibrogenesis, loss of cellular retinoid and change of cell-shape. Here, we have described fundamental differences between freshly isolated Ito cells (FIC) and long-term cultured Ito cells (LTIC). This process of activation...
Topics
- Animals
- Base Sequence
- Cells, Cultured
- Collagen
- DNA
- Gene Deletion
- Gene Expression Regulation
- Genes, jun
- Liver
- Molecular Sequence Data
- Phenotype
- Promoter Regions, Genetic