Article
The effects of cardiac myocytes on interstitial fibroblasts in toxic iron overload.
Cardiovascular toxicology - 1 Jan 2001
Liu Y, Templeton D M
Abstract excerpt
Iron deposits preferentially in myocytes in mixed cultures of cardiac myocytes and nonmyocytic fibroblasts. In vivo, iron overload is associated with cardiac fibrosis. Therefore, we examined whether iron loading of cardiac myocytes in culture could trigger a response in nonmyocytes characteristic of a fibrogenic phenotype. We found that the nonmyocytes adopted a myofibroblast phenotype in culture. The rate of DNA...
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