Article
Ito-cell gene expression and collagen regulation.
Hepatology (Baltimore, Md.) - 1 Jan 1990
Weiner F R, Giambrone M A, Czaja M J, Shah A, Annoni G, Takahashi S, Eghbali M, Zern M A
Abstract excerpt
Ito cells are perisinusoidal cells thought to be a major source of collagen in normal and fibrotic livers. These cells appear to have features similar to several cell types but when cultured assume a fibroblast-like morphology. In this study we evaluated the phenotype of both freshly isolated and cultured Ito cells by examining their gene expression. To better define the modulators of Ito-cell collagen synthesis,...
Topics
- Adipose Tissue
- Animals
- Cells, Cultured
- Collagen
- Gene Expression
- Liver
- Male
- Phenotype
- Procollagen
- RNA, Messenger
- Rats
- Rats, Inbred Strains