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Article

Purine analog substitution of the HIV-1 polypurine tract primer defines regions controlling initiation of plus-strand DNA synthesis.

Nucleic acids research - 1 Jan 2007

Rausch Jason W, Le Grice Stuart F J

Abstract excerpt

Despite extensive study, the mechanism by which retroviral reverse transciptases (RTs) specifically utilize polypurine tract (PPT) RNA for initiation of plus-strand DNA synthesis remains unclear. Three sequence motifs within or adjacent to the purine-rich elements are highly conserved, namely, a rU:dA tract region immediately 5' to the PPT, an rA:dT-rich sequence constituting the upstream portion of the PPT and a...

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Identifiers

PMID: 17164285
DOI: 10.1093/nar/gkl909
PMCID: PMC1802577

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DAP

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