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Article

Pa-AGOG, the founding member of a new family of archaeal 8-oxoguanine DNA-glycosylases.

Nucleic acids research - 1 Jan 2004

Sartori Alessandro A, Lingaraju Gondichatnahalli M, Hunziker Peter, Winkler Fritz K, Jiricny Josef

Abstract excerpt

Oxidative damage represents a major threat to genomic stability, as the major product of DNA oxidation, 8-oxoguanine (GO), frequently mispairs with adenine during replication. In order to prevent these mutagenic events, organisms have evolved GO-DNA glycosylases that remove this oxidized base from DNA. We were interested to find out how GO is processed in the hyperthermophilic archaeon Pyrobaculum aerophilum,...

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Identifiers

PMID: 15604455
DOI: 10.1093/nar/gkh995
PMCID: PMC545463

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