Article
Biochemical characterization of uracil processing activities in the hyperthermophilic archaeon Pyrobaculum aerophilum.
The Journal of biological chemistry - 10 Aug 2001
Sartori A A, Schär P, Fitz-Gibbon S, Miller J H, Jiricny J
Abstract excerpt
Deamination of cytosine to uracil and 5-methylcytosine to thymine represents a major mutagenic threat particularly at high temperatures. In double-stranded DNA, these spontaneous hydrolytic reactions give rise to G.U and G.T mispairs, respectively, that must be restored to G.C pairs prior to the next round of DNA replication; if left unrepaired, 50% of progeny DNA would acquire G.C --> A.T transition mutations....
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