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Article

Uracil in duplex DNA is a substrate for the nucleotide incision repair pathway in human cells

10 Sept 2013

Abstract excerpt

Spontaneous hydrolytic deamination of cytosine to uracil (U) in DNA is a constant source of genome instability in cells. This mutagenic process is greatly enhanced at high temperatures and in single-stranded DNA. If not repaired, these uracil residues give rise to C → T transitions, which are the most common spontaneous mutations occurring in living organisms and are frequently found in human tumors. In the...

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PMID: 24023064
DOI: 10.1073/pnas.1305624110

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