Article
Structural comparison of AP endonucleases from the exonuclease III family reveals new amino acid residues in human AP endonuclease 1 that are involved in incision of damaged DNA.
Biochimie - 1 Jan 2000
Redrejo-Rodríguez Modesto, Vigouroux Armelle, Mursalimov Aibek, Grin Inga, Alili Doria, Koshenov Zhanat, Akishev Zhiger, Maksimenko Andrei, Bissenbaev Amangeldy K, Matkarimov Bakhyt T, Saparbaev Murat, Ishchenko Alexander A, Moréra Solange
Abstract excerpt
Oxidatively damaged DNA bases are substrates for two overlapping repair pathways: DNA glycosylase-initiated base excision repair (BER) and apurinic/apyrimidinic (AP) endonuclease-initiated nucleotide incision repair (NIR). In the BER pathway, an AP endonuclease cleaves DNA at AP sites and 3'-blocking moieties generated by DNA glycosylases, whereas in the NIR pathway, the same AP endonuclease incises DNA 5' to an...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.