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Article

Nutrient availability regulates SIRT1 through a forkhead-dependent pathway.

Science (New York, N.Y.) - 17 Dec 2004

Nemoto Shino, Fergusson Maria M, Finkel Toren

Abstract excerpt

Nutrient availability regulates life-span in a wide range of organisms. We demonstrate that in mammalian cells, acute nutrient withdrawal simultaneously augments expression of the SIRT1 deacetylase and activates the Forkhead transcription factor Foxo3a. Knockdown of Foxo3a expression inhibited the starvation-induced increase in SIRT1 expression. Stimulation of SIRT1 transcription by Foxo3a was mediated through...

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Source

Identifiers

PMID: 15604409
DOI: 10.1126/science.1101731

Genes

SIRT1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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