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Article

Insulin-like growth factor-1 regulates the SIRT1-p53 pathway in cellular senescence.

Aging cell - 1 Aug 2014

Tran Duc, Bergholz Johann, Zhang Haibo, He Hanbing, Wang Yang, Zhang Yujun, Li Qintong, Kirkland James L, Xiao Zhi-Xiong

Abstract excerpt

Cellular senescence, which is known to halt proliferation of aged and stressed cells, plays a key role against cancer development and is also closely associated with organismal aging. While increased insulin-like growth factor (IGF) signaling induces cell proliferation, survival and cancer progression, disrupted IGF signaling is known to enhance longevity concomitantly with delay in aging processes. The molecular...

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Source

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Identifiers

PMID: 25070626
DOI: 10.1111/acel.12219
PMCID: PMC4118446

Genes

SIRT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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