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Article

Caloric restriction: is mammalian life extension linked to p53?

22 Aug 2012

Abstract excerpt

Caloric restriction, that is limiting food intake, is recognized in mammals as the best characterized and most reproducible strategy for extending lifespan, retarding physiological aging and delaying the onset of age-associated diseases. The aim of this mini review is to argue that p53 is the connection in the abilities of both the Sirt-1 pathway and the TOR pathway to impact on longevity of cells and organisms....

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PMID: 22983298
DOI: 10.18632/aging.100481

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