Article
SIRT3 overexpression antagonizes high glucose accelerated cellular senescence in human diploid fibroblasts via the SIRT3-FOXO1 signaling pathway.
Age (Dordrecht, Netherlands) - 1 Dec 2013
Zhang Bin, Cui Shaoyuan, Bai Xueyuan, Zhuo Li, Sun Xuefeng, Hong Quan, Fu Bo, Wang Jianzhong, Chen Xiangmei, Cai Guangyan
Abstract excerpt
Sirtuin 3 (SIRT3) is one of the seven mammalian sirtuins, which are homologs of the yeast Sir2 gene. SIRT3 is the only sirtuin reported to be associated with human life span. Many recent studies have indicated that SIRT3 levels are elevated by exercise and caloric restriction, but whether SIRT3 influences cell senescence under stressed conditions in human diploid fibroblasts has not been established. Our data...
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