Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

SIRT1: Linking Adaptive Cellular Responses to Aging-Associated Changes in Organismal Physiology

22 Nov 2006

Abstract excerpt

Sirtuins comprise a family of enzymes implicated in the determination of organismal life span in yeast and the nematode. The mammalian sirtuin SIRT1 has been shown to deacetylate several proteins in an NAD(+)-dependent manner. SIRT1 substrates are involved in the regulation of apoptosis/cell survival, endocrine signaling, differentiation, chromatin remodeling, and transcription. Thus SIRT1 provides a molecular...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autophagy in Disease and Therapy
Share to Sirtuins and Resveratrol in Medicine
Share to Tea Polyphenols and Effects

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 17119153
DOI: 10.1152/physiol.00031.2006

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

SIRT1: Linking Adaptive Cellular Responses to Aging-Associated Changes in Organismal PhysiologyPMID 17119153Read ↗

Mammalian Sirtuins: Biological Insights and Disease RelevanceSemantic proximity Read ↗

Epigenetic Regulation of Human Sirtuin 1 Insights into Aging MechanismsSemantic proximity Read ↗

From Sirtuin Biology to Human Diseases: An UpdateSemantic proximity Read ↗

SIRT1: roles in aging and cancerSemantic proximity Read ↗

SIRT1 and SIRT6: The role in aging-related diseasesSemantic proximity Read ↗

Aging and disease: connections to sirtuinsSemantic proximity Read ↗

Sirtuins in mammals: insights into their biological functionSemantic proximity Read ↗

Role of sirtuins in epigenetic regulation and aging controlSemantic proximity Read ↗

SIRTain regulators of premature senescence and accelerated agingSemantic proximity Read ↗

SIRT1, resveratrol and agingSemantic proximity Read ↗

The role of sirtuin 1 in ageing and neurodegenerative disease: A molecular perspectiveSemantic proximity Read ↗

SIRT1: new avenues of discovery for disorders of oxidative stressSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.