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Article

A single-nucleotide variation in a p53-binding site affects nutrient-sensitive human SIRT1 expression.

Human molecular genetics - 1 Nov 2010

Naqvi Asma, Hoffman Timothy A, DeRicco Jeremy, Kumar Ajay, Kim Cuk-Seong, Jung Saet-Byel, Yamamori Tohru, Kim Young-Rae, Mehdi Fardeen, Kumar Santosh, Rankinen Tuomo, Ravussin Eric, Irani Kaikobad

Abstract excerpt

The SIRTUIN1 (SIRT1) deacetylase responds to changes in nutrient availability and regulates mammalian physiology and metabolism. Human and mouse SIRT1 are transcriptionally repressed by p53 via p53 response elements in their proximal promoters. Here, we identify a novel p53-binding sequence in th...

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Share to Binding, Competitive
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Caloric Restriction

Share to Promoter Regions, Genetic

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Share to Tumor Suppressor Protein p53

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Source

Open in PubMed Open full text

Identifiers

PMID: 20693263
DOI: 10.1093/hmg/ddq331
PMCID: PMC2951863

Genes

SIRT1
HIC1
PGC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20693263-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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