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Article

SIRT1 and caloric restriction: an insight into possible trade-offs between robustness and frailty

8 Jun 2009

Abstract excerpt

PURPOSE OF REVIEW: This review aims to summarize the importance of the mammalian nicotinamide adenine dinucleotide (NAD)-dependent deacetylase SIRT1 as a critical mediator that coordinates metabolic responses to caloric restriction and the recent progress in the development of SIRT1-targeted caloric restriction mimetics. It also discusses possible trade-offs between robustness and frailty in caloric restriction...

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PMID: 19474721
DOI: 10.1097/mco.0b013e32832c932d

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