Article
Serum from calorie-restricted animals delays senescence and extends the lifespan of normal human fibroblasts in vitro.
Aging - 1 Mar 2015
de Cabo Rafael, Liu Lijuan, Ali Ahmed, Price Nathan, Zhang Jing, Wang Mingyi, Lakatta Edward, Irusta Pablo M
Abstract excerpt
The cumulative effects of cellular senescence and cell loss over time in various tissues and organs are considered major contributing factors to the ageing process. In various organisms, caloric restriction (CR) slows ageing and increases lifespan, at least in part, by activating nicotinamide adenine dinucleotide (NAD+)-dependent protein deacetylases of the sirtuin family. Here, we use an in vitro model of CR to...
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