Article
Genome-wide association identifies the T gene as a novel asthma pharmacogenetic locus.
American journal of respiratory and critical care medicine - 15 Jun 2012
Tantisira Kelan G, Damask Amy, Szefler Stanley J, Schuemann Brooke, Markezich Amy, Su Jessica, Klanderman Barbara, Sylvia Jody, Wu Rongling, Martinez Fernando, Boushey Homer A, Chinchilli Vernon M, Mauger Dave, Weiss Scott T, Israel Elliot
Abstract excerpt
RATIONALE: To date, most studies aimed at discovering genetic factors influencing treatment response in asthma have focused on biologic candidate genes. Genome-wide association studies (GWAS) can rapidly identify novel pharmacogenetic loci. OBJECTIVES: To investigate if GWAS can identify novel pharmacogenetic loci in asthma. METHODS: Using phenotypic and GWAS genotype data available through the NHLBI-funded...
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