A naturally occurring mutation in Fc gamma RIIA: a Q to K127 change confers unique IgG binding properties to the R131 allelic form of the receptor.

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Article

A naturally occurring mutation in Fc gamma RIIA: a Q to K127 change confers unique IgG binding properties to the R131 allelic form of the receptor.

Blood - 15 Jan 1998

Norris C F, Pricop L, Millard S S, Taylor S M, Surrey S, Schwartz E, Salmon J E, McKenzie S E

Abstract excerpt

Fc gamma RIIa is widely expressed on hematopoietic cells. There are two known allelic polymorphic forms of Fc gamma RIIa, Fc gamma RIIa-R131 and Fc gamma RIIa-H131, which differ in the amino acid at position 131 in the second lg-like domain. In contrast to Fc gamma RIIa-R131, Fc gamma RIIa-H131 b...

Topics

Alleles
Amino Acid Sequence
Antigens, CD
Binding Sites
Homozygote
Humans
Immunoglobulin G
Molecular Sequence Data
Monocytes
Mutation
Neutrophils
Polymorphism, Genetic
Receptors, IgG

Source

Open in PubMed

Identifiers

PMID: 9427722

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9427722-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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