Article
Pyrosequencing for classification of human FcγRIIIA allotypes: a comparison with PCR-based techniques.
Molecular diagnosis & therapy - 1 Dec 2014
Matlawska-Wasowska Ksenia, Gale James M, Nickl Christian K, Khalili Parisa, Shirley Brian, Wilson Bridget S, Vasef Mohammad A, Winter Stuart S
Abstract excerpt
BACKGROUND: Surface-specific antigens expressed by hematopoietic cells are attractive targets for antibody-mediated immunotherapy. Monoclonal antibodies (mAbs) involve various mechanisms to eliminate target cells, including antibody-dependent cellular cytotoxicity (ADCC)- and phagocytosis (ADCP)-mediated killing through natural killer (NK) and macrophage effector cells bearing FcγRIIIA (CD16). The clinical...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
