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Article

Peptide conjugates for chromosomal gene targeting by triplex-forming oligonucleotides.

Nucleic acids research - 1 Jan 2004

Rogers Faye A, Manoharan Muthiah, Rabinovitch Peter, Ward David C, Glazer Peter M

Abstract excerpt

Triplex-forming oligonucleotides (TFOs) are DNA-binding molecules, which offer the potential to selectively modulate gene expression. However, the biological activity of TFOs as potential antigene compounds has been limited by cellular uptake. Here, we investigate the effect of cell-penetrating peptides on the biological activity of TFOs as measured in an assay for gene-targeted mutagenesis. Using the transport...

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Identifiers

PMID: 15602001
DOI: 10.1093/nar/gkh998
PMCID: PMC545466

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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