Article
Specific mutations induced by triplex-forming oligonucleotides in mice.
Science (New York, N.Y.) - 20 Oct 2000
Vasquez K M, Narayanan L, Glazer P M
Abstract excerpt
Triplex-forming oligonucleotides (TFOs) recognize and bind to specific duplex DNA sequences and have been used extensively to modify gene function in cells. Although germ line mutations can be incorporated by means of embryonic stem cell technology, little progress has been made toward introducing mutations in somatic cells of living organisms. Here we demonstrate that TFOs can induce mutations at specific...
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