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Article

Proteasome-mediated degradation of cotranslationally damaged proteins involves translation elongation factor 1A.

Molecular and cellular biology - 1 Jan 2005

Chuang Show-Mei, Chen Li, Lambertson David, Anand Monika, Kinzy Terri Goss, Madura Kiran

Abstract excerpt

Rad23 and Rpn10 play synergistic roles in the recognition of ubiquitinated proteins by the proteasome, and loss of both proteins causes growth and proteolytic defects. However, the physiological targets of Rad23 and Rpn10 have not been well defined. We report that rad23Delta rpn10Delta is unable to grow in the presence of translation inhibitors, and this sensitivity was suppressed by translation elongation factor...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 15601860
DOI: 10.1128/MCB.25.1.403-413.2005
PMCID: PMC538794

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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