Article
Crt10 directs the cullin-E3 ligase Rtt101 to nonfunctional 25S rRNA decay.
Biochemical and biophysical research communications - 30 Jan 2015
Sakata Tomoko, Fujii Kotaro, Ohno Mutsuhito, Kitabatake Makoto
Abstract excerpt
Nonfunctional mutant ribosomal RNAs in 40S or 60S subunits are selectively degraded in eukaryotic cells (nonfunctional rRNA decay, NRD). We previously reported that NRD of 25S rRNA required cullin-E3 ligase Rtt101 and its associating factor Mms1, both of which are involved in DNA repair. Although Mms22, an accessory component of the E3 complex, was suggested to direct the E3 complex to DNA repair, the factor that...
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