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Article

The E3 ubiquitin ligase RNF10 modifies 40S ribosomal subunits of ribosomes compromised in translation.

Cell reports - 3 Aug 2021

Garzia Aitor, Meyer Cindy, Tuschl Thomas

Abstract excerpt

Reversible monoubiquitination of small subunit ribosomal proteins RPS2/uS5 and RPS3/uS3 has been noted to occur on ribosomes involved in ZNF598-dependent mRNA surveillance. Subsequent deubiquitination of RPS2 and RPS3 by USP10 is critical for recycling of stalled ribosomes in a process known as ribosome-associated quality control. Here, we identify and characterize the RPS2- and RPS3-specific E3 ligase Really...

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Identifiers

PMID: 34348161
DOI: 10.1016/j.celrep.2021.109468

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