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Article

c-Kit triggers dual phosphorylations, which couple activation and degradation of the essential melanocyte factor Mi.

Genes & development - 1 Feb 2000

Wu M, Hemesath T J, Takemoto C M, Horstmann M A, Wells A G, Price E R, Fisher D Z, Fisher D E

Abstract excerpt

Microphthalmia (Mi) is a bHLHZip transcription factor that is essential for melanocyte development and postnatal function. It is thought to regulate both differentiated features of melanocytes such as pigmentation as well as proliferation/survival, based on phenotypes of mutant mouse alleles. Mi activity is controlled by at least two signaling pathways. Melanocyte-stimulating hormone (MSH) promotes transcription...

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Identifiers

PMID: 10673502
PMCID: PMC316361

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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