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Article

Mutagenic potential of benzo[a]pyrene-derived DNA adducts positioned in codon 273 of the human P53 gene.

Biochemistry - 21 Dec 2004

Dong Huan, Bonala Radha Rani, Suzuki Naomi, Johnson Francis, Grollman Arthur P, Shibutani Shinya

Abstract excerpt

Codon 273 ((5)(')CGT) of the human P53 gene is a mutational hot spot for the environmental carcinogen benzo[a]pyrene. We incorporated a single (+)- or (-)-trans-anti-benzo[a]pyrene diol epoxide (BPDE) DNA adduct at the second position of codon 273 of the human P53 gene and explored the mutagenic potential of this lesion in mammalian cells. Oligodeoxyribonucleotides ((5)(')GAGGTGCG(BPDE)TGTTTGT) modified with (+)-...

Topics

7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide
Animals
Base Sequence
COS Cells
Chlorocebus aethiops
Codon
Cytosine
DNA Adducts
DNA Methylation
DNA, Single-Stranded
Genes, p53

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Molecular Sequence Data

Mutagenesis

Mutation

Plasmids

Source

Identifiers

PMID: 15595848
DOI: 10.1021/bi0482194

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-15595848-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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