Article
Benzo[a]pyrene-induced murine skin tumors exhibit frequent and characteristic G to T mutations in the p53 gene.
Proceedings of the National Academy of Sciences of the United States of America - 1 Feb 1993
Ruggeri B, DiRado M, Zhang S Y, Bauer B, Goodrow T, Klein-Szanto A J
Abstract excerpt
Human tobacco-related cancers exhibit a high frequency of G to T transversions in the mutation hot spot region of the p53 tumor suppressor gene, possibly the result of specific mutagens in tobacco smoke, most notably benzo[a]pyrene (B[a]P). No in vivo animal model of B[a]P-induced tumorigenesis has been used, however, to substantiate these molecular epidemiological data experimentally. Direct DNA sequence...
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