Shaping genetic alterations in human cancer: the p53 mutation paradigm.

doi:10.1016/j.ccr.2007.10.001

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Article

Shaping genetic alterations in human cancer: the p53 mutation paradigm.

Cancer cell - 1 Oct 2007

Soussi Thierry, Wiman Klas G

Abstract excerpt

p53 mutations are found in 50% of human cancers. Molecular epidemiology has shown strong correlations between the spectrum of p53 mutations and exposure to exogenous carcinogens. This spectrum is influenced quantitatively and qualitatively by various upstream genetic filters that modulate carcinogen activation, detoxification, and/or DNA repair. In this review, we will discuss how other factors such as tissue...

Topics

BRCA1 Protein
DNA Damage
Exons
Gene Expression Regulation, Neoplastic
Humans
Microsatellite Instability
Mutation
Neoplasms
PTEN Phosphohydrolase
Polymorphism, Single Nucleotide
Proto-Oncogene Proteins c-akt
Proto-Oncogene Proteins c-mdm2
Signal Transduction
Tumor Suppressor Protein p53
Vascular Endothelial Growth Factor Receptor-1

Source

Open in PubMed

Identifiers

PMID: 17936556
DOI: 10.1016/j.ccr.2007.10.001

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