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Article

Aurora-A phosphorylates, activates, and relocalizes the small GTPase RalA.

Molecular and cellular biology - 1 Jan 2010

Lim Kian-Huat, Brady Donita C, Kashatus David F, Ancrile Brooke B, Der Channing J, Cox Adrienne D, Counter Christopher M

Abstract excerpt

The small GTPase Ras, which transmits extracellular signals to the cell, and the kinase Aurora-A, which promotes proper mitosis, can both be inappropriately activated in human tumors. Here, we show that Aurora-A in conjunction with oncogenic Ras enhances transformed cell growth. Furthermore, such...

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Source

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Identifiers

PMID: 19901077
DOI: 10.1128/MCB.00916-08
PMCID: PMC2798468

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19901077-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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