Article
Reduced serotonin transporter availability decreases prefrontal control of the amygdala.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 22 May 2013
Volman Inge, Verhagen Lennart, den Ouden Hanneke E M, Fernández Guillén, Rijpkema Mark, Franke Barbara, Toni Ivan, Roelofs Karin
Abstract excerpt
After a threatening event, the risk of developing social psychopathologies is increased in short-allele (s) carriers of the serotonin transporter gene. The amygdala becomes overresponsive to emotional stimuli, an effect that could be driven by local hypersensitivity or by reduced prefrontal regulation. This study distinguishes between these two hypotheses by using dynamic causal modeling of fMRI data acquired in...
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